Silent hyperlipidaemia modulated vascular endothelial markers

The aetiology of ischemic heart diseases is mainly based on atherosclerosis coronary artery. Inflammation and oxidative reactions are initiating aggravating the illness resulting in pathological remodelling vasculaturze at site injury. Endothelium lining blood vessels participated reaction biochemically through releasing some proteins into circulatory system which further complicate condition. aim this study was to determine early diagnosed hyperlipidaemia-associated changes plasma level these endothelial biomolecules. Compared healthy control, hyperlipidaemic patients have significantly increased arginase, metalloendopeptidase, peroxidase, myeloperoxidase, peroxynitrite with concomitant reduction arylesterase nitric oxide. present concluded that hyperlipidaemia play a great role modulation certain protein markers might be directly related patient condition or could used as tool for diagnosis follow up indicating stage vasculature remodelling, healing, inflammation resolution.